Good guide, bad guide: spacer sequence-dependent cleavage efficiency of Cas12a

Genome editing has recently made a revolutionary development with the introduction of the CRISPR–Cas technology. The programmable CRISPR-associated Cas9 and Cas12a nucleases generate specific dsDNA breaks in the genome, after which host DNA-repair mechanisms can be manipulated to implement the desir...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Creutzburg, Sjoerd C A, Wu, Wen Y, Mohanraju, Prarthana, Swartjes, Thomas, Alkan, Ferhat, Gorodkin, Jan, Staals, Raymond H J, van der Oost, John
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
RNA and RNA-protein complexes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102956/
https://ncbi.nlm.nih.gov/pubmed/31989168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1240
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