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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

The recent emergence of the novel, pathogenic SARS-coronavirus 2 (SARS-CoV-2) in China and its rapid national and international spread pose a global health emergency. Cell entry of coronaviruses depends on binding of the viral spike (S) proteins to cellular receptors and on S protein priming by host...

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Publicado no:Cell
Main Authors: Hoffmann, Markus, Kleine-Weber, Hannah, Schroeder, Simon, Krüger, Nadine, Herrler, Tanja, Erichsen, Sandra, Schiergens, Tobias S., Herrler, Georg, Wu, Nai-Huei, Nitsche, Andreas, Müller, Marcel A., Drosten, Christian, Pöhlmann, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Inc. 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7102627/
https://ncbi.nlm.nih.gov/pubmed/32142651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.02.052
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