Polymorphisms in dipeptidyl peptidase 4 reduce host cell entry of Middle East respiratory syndrome coronavirus

Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) causes a severe respiratory disease in humans. The MERS-CoV spike (S) glycoprotein mediates viral entry into target cells. For this, MERS-CoV S engages the host cell protein dipeptidyl peptidase 4 (DPP4, CD26) and the interface between M...

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Publicat a:Emerg Microbes Infect
Autors principals: Kleine-Weber, Hannah, Schroeder, Simon, Krüger, Nadine, Prokscha, Alexander, Naim, Hassan Y., Müller, Marcel A., Drosten, Christian, Pöhlmann, Stefan, Hoffmann, Markus
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2020
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7006675/
https://ncbi.nlm.nih.gov/pubmed/31964246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/22221751.2020.1713705
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