Adenosine Deaminase Acts as a Natural Antagonist for Dipeptidyl Peptidase 4-Mediated Entry of the Middle East Respiratory Syndrome Coronavirus

Middle East respiratory syndrome coronavirus (MERS-CoV) replicates in cells of different species using dipeptidyl peptidase 4 (DPP4) as a functional receptor. Here we show the resistance of ferrets to MERS-CoV infection and inability of ferret DDP4 to bind MERS-CoV. Site-directed mutagenesis of amin...

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Main Authors: Raj, V. Stalin, Smits, Saskia L., Provacia, Lisette B., van den Brand, Judith M. A., Wiersma, Lidewij, Ouwendijk, Werner J. D., Bestebroer, Theo M., Spronken, Monique I., van Amerongen, Geert, Rottier, Peter J. M., Fouchier, Ron A. M., Bosch, Berend Jan, Osterhaus, Albert D.M.E., Haagmans, Bart L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911594/
https://ncbi.nlm.nih.gov/pubmed/24257613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02935-13
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