Adenosine Deaminase Acts as a Natural Antagonist for Dipeptidyl Peptidase 4-Mediated Entry of the Middle East Respiratory Syndrome Coronavirus

Middle East respiratory syndrome coronavirus (MERS-CoV) replicates in cells of different species using dipeptidyl peptidase 4 (DPP4) as a functional receptor. Here we show the resistance of ferrets to MERS-CoV infection and inability of ferret DDP4 to bind MERS-CoV. Site-directed mutagenesis of amin...

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Hlavní autoři: Raj, V. Stalin, Smits, Saskia L., Provacia, Lisette B., van den Brand, Judith M. A., Wiersma, Lidewij, Ouwendijk, Werner J. D., Bestebroer, Theo M., Spronken, Monique I., van Amerongen, Geert, Rottier, Peter J. M., Fouchier, Ron A. M., Bosch, Berend Jan, Osterhaus, Albert D.M.E., Haagmans, Bart L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Virus-Cell Interactions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911594/
https://ncbi.nlm.nih.gov/pubmed/24257613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02935-13
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