Histone deacetylases 1 and 2 restrain CD4(+) cytotoxic T lymphocyte differentiation

Some effector CD4(+) T cell subsets display cytotoxic activity, thus breaking the functional dichotomy of CD4(+) helper and CD8(+) cytotoxic T lymphocytes. However, molecular mechanisms regulating CD4(+) cytotoxic T lymphocyte (CD4(+) CTL) differentiation are poorly understood. Here we show that lev...

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Pubblicato in:JCI Insight
Autori principali: Preglej, Teresa, Hamminger, Patricia, Luu, Maik, Bulat, Tanja, Andersen, Liisa, Göschl, Lisa, Stolz, Valentina, Rica, Ramona, Sandner, Lisa, Waltenberger, Darina, Tschismarov, Roland, Faux, Thomas, Boenke, Thorina, Laiho, Asta, Elo, Laura L., Sakaguchi, Shinya, Steiner, Günter, Decker, Thomas, Bohle, Barbara, Visekruna, Alexander, Bock, Christoph, Strobl, Birgit, Seiser, Christian, Boucheron, Nicole, Ellmeier, Wilfried
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7101144/
https://ncbi.nlm.nih.gov/pubmed/32102981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.133393
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