WIP1 dephosphorylation of p27(Kip1) Serine 140 destabilizes p27(Kip1) and reverses anti-proliferative effects of ATM phosphorylation

The phosphoinositide-3-kinase like kinases (PIKK) such as ATM and ATR play a key role in initiating the cellular DNA damage response (DDR). One key ATM target is the cyclin-dependent kinase inhibitor p27(Kip1) that promotes G1 arrest. ATM activates p27(Kip1)-induced arrest in part through phosphoryl...

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Опубликовано в: :Cell Cycle
Главные авторы: Choi, Byung-Kwon, Fujiwara, Kenichiro, Dayaram, Tajhal, Darlington, Yolanda, Dickerson, Joshua, Goodell, Margaret A., Donehower, Lawrence A.
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 2020
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7100888/
https://ncbi.nlm.nih.gov/pubmed/31959038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2020.1717025
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