A comprehensive analysis of methods for assessing polygenic burden on Alzheimer’s disease pathology and risk beyond APOE

Genome-wide association studies have identified dozens of loci that alter the risk to develop Alzheimer’s disease. However, with the exception of the APOE-ε4 allele, most variants bear only little individual effect and have, therefore, limited diagnostic and prognostic value. Polygenic risk scores a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Brain Commun
Prif Awduron: Altmann, Andre, Scelsi, Marzia A, Shoai, Maryam, de Silva, Eric, Aksman, Leon M, Cash, David M, Hardy, John, Schott, Jonathan M
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2019
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7100005/
https://ncbi.nlm.nih.gov/pubmed/32226939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/braincomms/fcz047
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