Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione redox system and enhances chemosensitivity in nonsmall cell lung cancer

Aldehyde dehydrogenases (ALDHs) are multifunctional enzymes that oxidize diverse endogenous and exogenous aldehydes. We conducted a meta-analysis based on The Cancer Genome Atlas and Gene Expression Omnibus data and detected genetic alterations in ALDH1A1, ALDH1A3, or ALDH3A1, 86% of which were gene...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Rebollido-Rios, Rocio, Venton, Geoffroy, Sánchez-Redondo, Sara, Iglesias i Felip, Carmela, Fournet, Guy, González, Elena, Romero Fernández, Wilber, Borroto Escuela, Dasiel Oscar, Di Stefano, Barbara, Penarroche-Díaz, Reinier, Martin, Guillaume, Ceylan, Ismail, Costello, Regis, Perez-Alea, Mileidys
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098886/
https://ncbi.nlm.nih.gov/pubmed/32015486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1184-9
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