Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione redox system and enhances chemosensitivity in nonsmall cell lung cancer

Aldehyde dehydrogenases (ALDHs) are multifunctional enzymes that oxidize diverse endogenous and exogenous aldehydes. We conducted a meta-analysis based on The Cancer Genome Atlas and Gene Expression Omnibus data and detected genetic alterations in ALDH1A1, ALDH1A3, or ALDH3A1, 86% of which were gene...

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Publicat a:Oncogene
Autors principals: Rebollido-Rios, Rocio, Venton, Geoffroy, Sánchez-Redondo, Sara, Iglesias i Felip, Carmela, Fournet, Guy, González, Elena, Romero Fernández, Wilber, Borroto Escuela, Dasiel Oscar, Di Stefano, Barbara, Penarroche-Díaz, Reinier, Martin, Guillaume, Ceylan, Ismail, Costello, Regis, Perez-Alea, Mileidys
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098886/
https://ncbi.nlm.nih.gov/pubmed/32015486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1184-9
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