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Antibody humanization—the Influence of the antibody framework on the CDR-H3 loop ensemble in solution
Antibody engineering of non-human antibodies has focused on reducing immunogenicity by humanization, being a major limitation in developing monoclonal antibodies. We analyzed four series of antibody binding fragments (Fabs) and a variable fragment (Fv) with structural information in different stages...
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| Publicado en: | Protein Eng Des Sel |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7098879/ https://ncbi.nlm.nih.gov/pubmed/32129452 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzaa004 |
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