Integrated drug profiling and CRISPR screening identify essential pathways for CAR T-cell cytotoxicity

Chimeric antigen receptor (CAR) T-cell therapy has proven effective in relapsed and refractory B-cell malignancies, but resistance and relapses still occur. Better understanding of mechanisms influencing CAR T-cell cytotoxicity and the potential for modulation using small-molecule drugs could improv...

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Bibliografische gegevens
Gepubliceerd in:Blood
Hoofdauteurs: Dufva, Olli, Koski, Jan, Maliniemi, Pilvi, Ianevski, Aleksandr, Klievink, Jay, Leitner, Judith, Pölönen, Petri, Hohtari, Helena, Saeed, Khalid, Hannunen, Tiina, Ellonen, Pekka, Steinberger, Peter, Kankainen, Matti, Aittokallio, Tero, Keränen, Mikko A. I., Korhonen, Matti, Mustjoki, Satu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2020
Onderwerpen:
Plenary Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098811/
https://ncbi.nlm.nih.gov/pubmed/31830245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019002121
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