SNAP23 depletion enables more SNAP25/calcium channel excitosome formation to increase insulin exocytosis in type 2 diabetes

SNAP23 is the ubiquitous SNAP25 isoform that mediates secretion in non-neuronal cells, similar to SNAP25 in neurons. However, some secretory cells like pancreatic islet β cells contain an abundance of both SNAP25 and SNAP23, where SNAP23 is believed to play a redundant role to SNAP25. We show that S...

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Foilsithe in:JCI Insight
Main Authors: Liang, Tao, Qin, Tairan, Kang, Fei, Kang, Youhou, Xie, Li, Zhu, Dan, Dolai, Subhankar, Greitzer-Antes, Dafna, Baker, Robert K., Feng, Daorong, Tuduri, Eva, Ostenson, Claes-Goran, Kieffer, Timothy J., Banks, Kate, Pessin, Jeffrey E., Gaisano, Herbert Y.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2020
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098801/
https://ncbi.nlm.nih.gov/pubmed/32051343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.129694
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