Arginine metabolic control of airway inflammation

Inducible nitric oxide synthase (iNOS) and arginase-2 (ARG2) share a common substrate, arginine. Higher expression of iNOS and exhaled NO are linked to airway inflammation in patients. iNOS deletion in animal models suggests that eosinophilic inflammation is regulated by arginine metabolism. Moreove...

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Udgivet i:JCI Insight
Main Authors: Asosingh, Kewal, Lauruschkat, Chris D., Alemagno, Mario, Frimel, Matthew, Wanner, Nicholas, Weiss, Kelly, Kessler, Sean, Meyers, Deborah A., Bennett, Carole, Xu, Weiling, Erzurum, Serpil
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098726/
https://ncbi.nlm.nih.gov/pubmed/31996482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127801
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