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Correlates of protective immunity for Ebola vaccines: implications for regulatory approval by the animal rule

Ebola virus infection is a highly lethal disease for which there are no effective therapeutic or preventive treatments. Several vaccines have provided immune protection in laboratory animals, but because outbreaks occur unpredictably and sporadically, vaccine efficacy cannot be proven in human trial...

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Detalhes bibliográficos
Publicado no:Nat Rev Microbiol
Main Authors: Sullivan, Nancy J., Martin, Julie E., Graham, Barney S., Nabel, Gary J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7097244/
https://ncbi.nlm.nih.gov/pubmed/19369954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrmicro2129
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