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Correlates of protective immunity for Ebola vaccines: implications for regulatory approval by the animal rule

Ebola virus infection is a highly lethal disease for which there are no effective therapeutic or preventive treatments. Several vaccines have provided immune protection in laboratory animals, but because outbreaks occur unpredictably and sporadically, vaccine efficacy cannot be proven in human trial...

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Bibliografiske detaljer
Udgivet i:Nat Rev Microbiol
Main Authors: Sullivan, Nancy J., Martin, Julie E., Graham, Barney S., Nabel, Gary J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7097244/
https://ncbi.nlm.nih.gov/pubmed/19369954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrmicro2129
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