PTPσ Knockdown in Lampreys Impairs Reticulospinal Axon Regeneration and Neuronal Survival After Spinal Cord Injury

Traumatic spinal cord injury (SCI) results in persistent functional deficits due to the lack of axon regeneration within the mammalian CNS. After SCI, chondroitin sulfate proteoglycans (CSPGs) inhibit axon regrowth via putative interactions with the LAR-family protein tyrosine phosphatases, PTPσ and...

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Publicat a:Front Cell Neurosci
Autors principals: Rodemer, William, Zhang, Guixin, Sinitsa, Isabelle, Hu, Jianli, Jin, Li-qing, Li, Shuxin, Selzer, Michael E.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Cellular Neuroscience
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7096546/
https://ncbi.nlm.nih.gov/pubmed/32265663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2020.00061
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