Orthotopic Patient-Derived Pancreatic Cancer Xenografts Engraft Into the Pancreatic Parenchyma, Metastasize and Induce Muscle Wasting to Recapitulate the Human Disease

OBJECTIVE: Limitations associated with current animal models serve as a major obstacle to reliable preclinical evaluation of therapies in pancreatic cancer (PC). In an effort to develop more reliable preclinical models, we have recently established a subcutaneous patient-derived xenograft (PDX) mode...

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Pubblicato in:Pancreas
Autori principali: Go, Kristina L., Delitto, Daniel, Judge, Sarah M., Gerber, Michael H., George, Thomas J., Behrns, Kevin E., Hughes, Steven J., Judge, Andrew R., Trevino, Jose G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7094873/
https://ncbi.nlm.nih.gov/pubmed/28609371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPA.0000000000000843
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