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Patient-Derived Xenograft Models for Pancreatic Adenocarcinoma Demonstrate Retention of Tumor Morphology through Incorporation of Murine Stromal Elements

Direct implantation of viable surgical specimens provides a representative preclinical platform in pancreatic adenocarcinoma. Patient-derived xenografts consistently demonstrate retained tumor morphology and genetic stability. However, the evolution of the tumor microenvironment over time remains po...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Delitto, Daniel, Pham, Kien, Vlada, Adrian C., Sarosi, George A., Thomas, Ryan M., Behrns, Kevin E., Liu, Chen, Hughes, Steven J., Wallet, Shannon M., Trevino, Jose G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4419203/
https://ncbi.nlm.nih.gov/pubmed/25770474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.01.016
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