Nicotine Reduces Survival via Augmentation of Paracrine HGF-MET Signaling in the Pancreatic Cancer Microenvironment

PURPOSE: The relationship between smoking and pancreatic cancer (PC) biology, particularly in the context of the heterogeneous microenvironment, remains incompletely defined. We hypothesized that nicotine exposure would lead to the augmentation of paracrine growth factor signaling between tumor-asso...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Delitto, Daniel, Zhang, Dongyu, Han, Song, Black, Brian S., Knowlton, Andrea E., Vlada, Adrian C., Sarosi, George A., Behrns, Kevin E., Thomas, Ryan M., Lu, Xiaomin, Liu, Chen, George, Thomas J., Hughes, Steven J., Wallet, Shannon M., Trevino, Jose G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818664/
https://ncbi.nlm.nih.gov/pubmed/26667487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-1256
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