The receptor tyrosine kinase AXL mediates nuclear translocation of the epidermal growth factor receptor

The epidermal growth factor receptor (EGFR) is a therapeutic target in patients with various cancers. Unfortunately, resistance to EGFR-targeted therapeutics is common. Previous studies identified two mechanisms of resistance to the EGFR monoclonal antibody cetuximab: Nuclear translocation of EGFR b...

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Vydáno v:Sci Signal
Hlavní autoři: Brand, Toni M., Iida, Mari, Corrigan, Kelsey L., Braverman, Cara M., Coan, John P., Flanigan, Bailey G., Stein, Andrew P., Salgia, Ravi, Rolff, Jana, Kimple, Randall J., Wheeler, Deric L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7094775/
https://ncbi.nlm.nih.gov/pubmed/28049763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aag1064
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