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Glycyrrhizic acid attenuates growth of Leishmania donovani by depleting ergosterol levels

In the present study, glycyrrhizic acid (GA) the main component of Glycyrrhiza glabra was evaluated for its efficacy as antileishmanial agent and its mode of action explored. GA inhibits promastigotes and intracellular amastigotes in a dose dependent manner at an IC(50) value of 34 ± 3.0 μM and 20 ±...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Exp Parasitol
Hauptverfasser: Dinesh, Neeradi, Neelagiri, Soumya, Kumar, Vinay, Singh, Sushma
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Inc. 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7094550/
https://ncbi.nlm.nih.gov/pubmed/28242356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exppara.2017.02.015
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