Mutational and Structural Analysis of Conserved Residues in Ribose-5-Phosphate Isomerase B from Leishmania donovani: Role in Substrate Recognition and Conformational Stability

Ribose-5-phosphate isomerase B from Leishmania donovani (LdRpiB) is one of the potential drug targets against visceral leishmaniasis. In the present study, we have targeted several conserved amino acids for mutational analysis (i.e. Cys69, His11, His102, His138, Asp45, Tyr46, Pro47 and Glu149) to ga...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Kaur, Preet Kamal, Tripathi, Neha, Desale, Jayesh, Neelagiri, Soumya, Yadav, Shailendra, Bharatam, Prasad V., Singh, Sushma
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783025/
https://ncbi.nlm.nih.gov/pubmed/26953696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150764
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