EDEM3 Modulates Plasma Triglyceride Level through Its Regulation of LRP1 Expression

Human genetics studies have uncovered genetic variants that can be used to guide biological research and prioritize molecular targets for therapeutic intervention for complex diseases. We have identified a missense variant (P746S) in EDEM3 associated with lower blood triglyceride (TG) levels in >...

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Détails bibliographiques
Publié dans:iScience
Auteurs principaux: Xu, Yu-Xin, Peloso, Gina M., Nagai, Taylor H., Mizoguchi, Taiji, Deik, Amy, Bullock, Kevin, Lin, Honghuang, Musunuru, Kiran, Yang, Qiong, Vasan, Ramachandran S., Gerszten, Robert E., Clish, Clary B., Rader, Daniel, Kathiresan, Sekar
Format: Artigo
Langue:Inglês
Publié: Elsevier 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7093811/
https://ncbi.nlm.nih.gov/pubmed/32213464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.100973
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