EDEM3 Modulates Plasma Triglyceride Level through Its Regulation of LRP1 Expression

Human genetics studies have uncovered genetic variants that can be used to guide biological research and prioritize molecular targets for therapeutic intervention for complex diseases. We have identified a missense variant (P746S) in EDEM3 associated with lower blood triglyceride (TG) levels in >...

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Bibliografski detalji
Izdano u:iScience
Glavni autori: Xu, Yu-Xin, Peloso, Gina M., Nagai, Taylor H., Mizoguchi, Taiji, Deik, Amy, Bullock, Kevin, Lin, Honghuang, Musunuru, Kiran, Yang, Qiong, Vasan, Ramachandran S., Gerszten, Robert E., Clish, Clary B., Rader, Daniel, Kathiresan, Sekar
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7093811/
https://ncbi.nlm.nih.gov/pubmed/32213464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.100973
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