Single-Molecule Force Spectroscopy on the N2A Element of Titin: Effects of Phosphorylation and CARP

Titin is a large filamentous protein that forms a sarcomeric myofilament with a molecular spring region that develops force in stretched sarcomeres. The molecular spring has a complex make-up that includes the N2A element. This element largely consists of a 104-residue unique sequence (N2A-Us) flank...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Lanzicher, Thomas, Zhou, Tiankun, Saripalli, Chandra, Keschrumrus, Vic, Smith III, John E., Mayans, Olga, Sbaizero, Orfeo, Granzier, Henk
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7093598/
https://ncbi.nlm.nih.gov/pubmed/32256378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.00173
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