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Sperm SPACA6 protein is required for mammalian Sperm-Egg Adhesion/Fusion

Three genes are known to be essential for gamete adhesion/fusion (Cd9, Izumo1 and Juno). Here, we confirmed that Spaca6 null males are infertile and showed that their sperm accumulate in the perivitelline space but are unable to fuse with oocyte. Like IZUMO1, SPACA6 which is expressed by human sperm...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Barbaux, Sandrine, Ialy-Radio, Côme, Chalbi, Myriam, Dybal, Elisa, Homps-Legrand, Méline, Do Cruzeiro, Marcio, Vaiman, Daniel, Wolf, Jean-Philippe, Ziyyat, Ahmed
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7093486/
https://ncbi.nlm.nih.gov/pubmed/32210282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-62091-y
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