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Sperm SPACA6 protein is required for mammalian Sperm-Egg Adhesion/Fusion

Three genes are known to be essential for gamete adhesion/fusion (Cd9, Izumo1 and Juno). Here, we confirmed that Spaca6 null males are infertile and showed that their sperm accumulate in the perivitelline space but are unable to fuse with oocyte. Like IZUMO1, SPACA6 which is expressed by human sperm...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Barbaux, Sandrine, Ialy-Radio, Côme, Chalbi, Myriam, Dybal, Elisa, Homps-Legrand, Méline, Do Cruzeiro, Marcio, Vaiman, Daniel, Wolf, Jean-Philippe, Ziyyat, Ahmed
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7093486/
https://ncbi.nlm.nih.gov/pubmed/32210282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-62091-y
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