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Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus
The papain-like protease of severe acute respiratory syndrome coronavirus (PLpro) (EC 3.4.22.46) is essential for the viral life cycle and therefore represents an important antiviral target. We have identified 6MP and 6TG as reversible and slow-binding inhibitors of SARS-CoV PLpro, which is the firs...
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| 出版年: | Biochem Pharmacol |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Elsevier Inc.
2008
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7092826/ https://ncbi.nlm.nih.gov/pubmed/18313035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2008.01.005 |
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