Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus

The papain-like protease of severe acute respiratory syndrome coronavirus (PLpro) (EC 3.4.22.46) is essential for the viral life cycle and therefore represents an important antiviral target. We have identified 6MP and 6TG as reversible and slow-binding inhibitors of SARS-CoV PLpro, which is the firs...

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Bibliografiske detaljer
Udgivet i:Biochem Pharmacol
Main Authors: Chou, Chi-Yuan, Chien, Chia-Hui, Han, Yu-San, Prebanda, Mojca Trstenjak, Hsieh, Hsing-Pang, Turk, Boris, Chang, Gu-Gang, Chen, Xin
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Inc. 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7092826/
https://ncbi.nlm.nih.gov/pubmed/18313035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2008.01.005
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