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The Interplay between Molten Globules and Heme Disassociation Defines Human Hemoglobin Disassembly
Hemoglobin functions as a tetrameric oxygen transport protein, with each subunit containing a heme cofactor. Its denaturation, either in vivo or in vitro, involves autoxidation to methemoglobin, followed by cofactor loss and globin unfolding. We have proposed a global disassembly scheme for human me...
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| Publicado en: | Biophys J |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Biophysical Society
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7091471/ https://ncbi.nlm.nih.gov/pubmed/32075750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.01.031 |
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