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Atomistic simulations of heme dissociation pathways in human methemoglobins reveal hidden intermediates
Heme dissociations disrupt function and structural integrity of human hemoglobin and trigger various cardiovascular complications. These events become significant in methemoglobins that have undergone autoxidation of ferrous into ferric heme. We have structurally characterized the heme disassociatio...
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| Publicado no: | Biochemistry |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8088502/ https://ncbi.nlm.nih.gov/pubmed/32945658 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00607 |
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