Mice Carrying ALS Mutant TDP-43, but Not Mutant FUS, Display In Vivo Defects in Axonal Transport of Signaling Endosomes

Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease resulting from a complex interplay between genetics and environment. Impairments in axonal transport have been identified in several ALS models, but in vivo evidence remains limited, thus their pathogenetic importa...

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Publicado en:Cell Rep
Autores principales: Sleigh, James N., Tosolini, Andrew P., Gordon, David, Devoy, Anny, Fratta, Pietro, Fisher, Elizabeth M.C., Talbot, Kevin, Schiavo, Giampietro
Formato: Artigo
Lenguaje:Inglês
Publicado: Cell Press 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7090381/
https://ncbi.nlm.nih.gov/pubmed/32187538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.02.078
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