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A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation
The N-terminal residue influences protein stability through N-end rule pathways. Here, through stability profiling of the human N-terminome, we uncover multiple new features of the N-end rule. In addition to uncovering new specificities of UBR E3 ligases, we characterize two related Cullin-RING E3 l...
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| Veröffentlicht in: | Science |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7090375/ https://ncbi.nlm.nih.gov/pubmed/31273098 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaw4912 |
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