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The Eukaryotic Proteome is Shaped by E3 Ubiquitin Ligases Targeting C-terminal Degrons

Degrons are minimal elements that mediate the interaction of proteins with degradation machineries to promote proteolysis. Despite their central role in proteostasis, the number of known degrons remains small and a facile technology to characterize them is lacking. Using a strategy combining Global...

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Bibliografische gegevens
Gepubliceerd in:Cell
Hoofdauteurs: Koren, Itay, Timms, Richard T., Kula, Tomasz, Xu, Qikai, Li, Mamie Z., Elledge, Stephen J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003881/
https://ncbi.nlm.nih.gov/pubmed/29779948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.04.028
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