Cul5-type Ubiquitin Ligase KLHDC1 Contributes to the Elimination of Truncated SELENOS Produced by Failed UGA/Sec Decoding

The UGA codon signals protein translation termination, but it can also be translated into selenocysteine (Sec, U) to produce selenocysteine-containing proteins (selenoproteins) by dedicated machinery. As Sec incorporation can fail, Sec-containing longer and Sec-lacking shorter proteins co-exist. Cul...

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Veröffentlicht in:iScience
Hauptverfasser: Okumura, Fumihiko, Fujiki, Yuha, Oki, Nodoka, Osaki, Kana, Nishikimi, Akihiko, Fukui, Yoshinori, Nakatsukasa, Kunio, Kamura, Takumi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7090344/
https://ncbi.nlm.nih.gov/pubmed/32200094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.100970
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