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Cross-linked Small Polyethylenimines: While Still Nontoxic, Deliver DNA Efficiently to Mammalian Cells in Vitro and in Vivo

PURPOSE. Polyethylenimine (PEI) is among the most efficient nonviral gene delivery vectors. Its efficiency and cytotoxicity depend on molecular weight, with the 25-kDa PEI being most efficient but cytotoxic. Smaller PEIs are noncytotoxic but less efficient. Enhancement in gene delivery efficiency wi...

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Vydáno v:Pharm Res
Hlavní autoři: Thomas, Mini, Ge, Qing, Lu, James J., Chen, Jianzhu, Klibanov, Alexander
Médium: Artigo
Jazyk:Inglês
Vydáno: Kluwer Academic Publishers-Plenum Publishers 2005
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7089549/
https://ncbi.nlm.nih.gov/pubmed/15835742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-004-1874-y
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