Cross-linked Small Polyethylenimines: While Still Nontoxic, Deliver DNA Efficiently to Mammalian Cells in Vitro and in Vivo

PURPOSE. Polyethylenimine (PEI) is among the most efficient nonviral gene delivery vectors. Its efficiency and cytotoxicity depend on molecular weight, with the 25-kDa PEI being most efficient but cytotoxic. Smaller PEIs are noncytotoxic but less efficient. Enhancement in gene delivery efficiency wi...

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Bibliografiske detaljer
Udgivet i:Pharm Res
Main Authors: Thomas, Mini, Ge, Qing, Lu, James J., Chen, Jianzhu, Klibanov, Alexander
Format: Artigo
Sprog:Inglês
Udgivet: Kluwer Academic Publishers-Plenum Publishers 2005
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7089549/
https://ncbi.nlm.nih.gov/pubmed/15835742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-004-1874-y
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