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Structural Insight into G Protein-Coupled Receptor Signaling Efficacy and Bias between Gs and β-Arrestin

[Image: see text] G protein-coupled receptors (GPCRs) form the largest family of membrane proteins involved in signal transduction. Because of their ability to regulate a wide range of cellular responses and their dysregulation being associated with many diseases, GPCRs remain a key therapeutic targ...

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Detalles Bibliográficos
Publicado en:ACS Pharmacol Transl Sci
Main Authors: Picard, Louis-Philippe, Schonegge, Anne-Marie, Bouvier, Michel
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2019
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7088954/
https://ncbi.nlm.nih.gov/pubmed/32259053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.9b00012
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