PA-X-associated early alleviation of the acute lung injury contributes to the attenuation of a highly pathogenic H5N1 avian influenza virus in mice

PA-X is a novel discovered accessory protein encoded by the PA mRNA. Our previous study demonstrated that PA-X decreases the virulence of a highly pathogenic H5N1 strain A/Chicken/Jiangsu/k0402/2010 in mice. However, the underlying mechanism of virulence attenuation associated with PA-X is still unk...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Med Microbiol Immunol
Hauptverfasser: Hu, Jiao, Mo, Yiqun, Gao, Zhao, Wang, Xiaoquan, Gu, Min, Liang, Yanyan, Cheng, Xin, Hu, Shunlin, Liu, Wenbo, Liu, Huimou, Chen, Sujuan, Liu, Xiaowen, Peng, Daxing, Liu, Xiufan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2016
Schlagworte:
Original Investigation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7086737/
https://ncbi.nlm.nih.gov/pubmed/27289459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00430-016-0461-2
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