Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays

The hallmark pathological features of Alzheimer's disease (AD) brains are senile plaques, comprising β-amyloid (Aβ) peptides, and neuronal inclusions formed from tau protein. These plaques form 10–20 years before AD symptom onset, whereas robust tau pathology is more closely associated with sym...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Crowe, Alex, Henderson, Mark J., Anderson, Johnathon, Titus, Steven A., Zakharov, Alexey, Simeonov, Anton, Buist, Arjan, Delay, Charlotte, Moechars, Diederik, Trojanowski, John Q., Lee, Virginia M.-Y., Brunden, Kurt R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2020
Fag:
Neurobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7086036/
https://ncbi.nlm.nih.gov/pubmed/32034092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010532
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