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Targeting MEK5 impairs non-homologous end-joining repair and sensitizes prostate cancer to DNA damaging agents
Radiotherapy is commonly used to treat a variety of solid human tumors, including localized prostate cancer. However, treatment failure often ensues due to tumor intrinsic or acquired radioresistance. Here we find that the MEK5/ERK5 signaling pathway is associated with resistance to genotoxic stress...
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| Publicado no: | Oncogene |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7085449/ https://ncbi.nlm.nih.gov/pubmed/31980741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1163-1 |
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