Modeling Damage Complexity-Dependent Non-Homologous End-Joining Repair Pathway

Non-homologous end joining (NHEJ) is the dominant DNA double strand break (DSB) repair pathway and involves several repair proteins such as Ku, DNA-PKcs, and XRCC4. It has been experimentally shown that the choice of NHEJ proteins is determined by the complexity of DSB. In this paper, we built a mat...

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Bibliographic Details
Main Authors: Li, Yongfeng, Reynolds, Pamela, O'Neill, Peter, Cucinotta, Francis A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3919704/
https://ncbi.nlm.nih.gov/pubmed/24520318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085816
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