Targeting MEK5 impairs non-homologous end-joining repair and sensitizes prostate cancer to DNA damaging agents

Radiotherapy is commonly used to treat a variety of solid human tumors, including localized prostate cancer. However, treatment failure often ensues due to tumor intrinsic or acquired radioresistance. Here we find that the MEK5/ERK5 signaling pathway is associated with resistance to genotoxic stress...

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Bibliografske podrobnosti
izdano v:Oncogene
Main Authors: Broustas, Constantinos G., Duval, Axel J., Chaudhary, Kunal R., Friedman, Richard A., Virk, Renu K., Lieberman, Howard B.
Format: Artigo
Jezik:Inglês
Izdano: 2020
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7085449/
https://ncbi.nlm.nih.gov/pubmed/31980741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1163-1
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