MYC Dysregulates Mitosis, Revealing Cancer Vulnerabilities

Tumors that overexpress the MYC oncogene are frequently aneuploid, a state associated with highly aggressive cancers and tumor evolution. However, how MYC causes aneuploidy is not well understood. Here, we show that MYC overexpression induces mitotic spindle assembly defects and chromosomal instabil...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Rohrberg, Julia, Van de Mark, Daniel, Amouzgar, Meelad, Lee, Joyce V., Taileb, Moufida, Corella, Alexandra, Kilinc, Seda, Williams, Jeremy, Jokisch, Marie-Lena, Camarda, Roman, Balakrishnan, Sanjeev, Shankar, Rama, Zhou, Alicia, Chang, Aaron N., Chen, Bin, Rugo, Hope S., Dumont, Sophie, Goga, Andrei
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7085414/
https://ncbi.nlm.nih.gov/pubmed/32160543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.02.041
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