Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8(+) T cell stemness and antitumor immunity

Interleukin (IL)-2 and IL-21 dichotomously shape CD8(+) T cell differentiation. IL-2 drives terminal differentiation, generating cells that are poorly effective against tumors, whereas IL-21 promotes stem cell memory T cells (T(SCM)) and antitumor responses. Here we investigated the role of metaboli...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Hermans, Dalton, Gautam, Sanjivan, García-Cañaveras, Juan C., Gromer, Daniel, Mitra, Suman, Spolski, Rosanne, Li, Peng, Christensen, Stephen, Nguyen, Rosa, Lin, Jian-Xin, Oh, Jangsuk, Du, Ning, Veenbergen, Sharon, Fioravanti, Jessica, Ebina-Shibuya, Risa, Bleck, Christopher, Neckers, Leonard M., Rabinowitz, Joshua D., Gattinoni, Luca, Leonard, Warren J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7084161/
https://ncbi.nlm.nih.gov/pubmed/32123114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1920413117
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