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Systematic identification of engineered methionines and oxaziridines for efficient, stable, and site-specific antibody bioconjugation
The field of chemical modification of proteins has been dominated by random modification of lysines or more site-specific labeling of cysteines, each with attendant challenges. Recently, we have developed oxaziridine chemistry for highly selective modification of methionine called redox-activated ch...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7084160/ https://ncbi.nlm.nih.gov/pubmed/32123103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1920561117 |
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