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Redox-based reagents for chemoselective methionine bioconjugation
Cysteine can be specifically functionalized by a myriad of acid-base conjugation strategies for applications ranging from probing protein function to antibody-drug conjugates and proteomics. In contrast, selective ligation to the other sulfur-containing amino acid, methionine, has been precluded by...
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| Udgivet i: | Science |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5827972/ https://ncbi.nlm.nih.gov/pubmed/28183972 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aal3316 |
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