Assessing thyroid cancer risk using polygenic risk scores

Genome-wide association studies (GWASs) have identified at least 10 single-nucleotide polymorphisms (SNPs) associated with papillary thyroid cancer (PTC) risk. Most of these SNPs are common variants with small to moderate effect sizes. Here we assessed the combined genetic effects of these variants...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Liyanarachchi, Sandya, Gudmundsson, Julius, Ferkingstad, Egil, He, Huiling, Jonasson, Jon G., Tragante, Vinicius, Asselbergs, Folkert W., Xu, Li, Kiemeney, Lambertus A., Netea-Maier, Romana T., Mayordomo, Jose I., Plantinga, Theo S., Hjartarson, Hannes, Hrafnkelsson, Jon, Sturgis, Erich M., Brock, Pamela, Nabhan, Fadi, Thorleifsson, Gudmar, Ringel, Matthew D., Stefansson, Kari, de la Chapelle, Albert
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7084156/
https://ncbi.nlm.nih.gov/pubmed/32132206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1919976117
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