Assessing thyroid cancer risk using polygenic risk scores

Genome-wide association studies (GWASs) have identified at least 10 single-nucleotide polymorphisms (SNPs) associated with papillary thyroid cancer (PTC) risk. Most of these SNPs are common variants with small to moderate effect sizes. Here we assessed the combined genetic effects of these variants...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Liyanarachchi, Sandya, Gudmundsson, Julius, Ferkingstad, Egil, He, Huiling, Jonasson, Jon G., Tragante, Vinicius, Asselbergs, Folkert W., Xu, Li, Kiemeney, Lambertus A., Netea-Maier, Romana T., Mayordomo, Jose I., Plantinga, Theo S., Hjartarson, Hannes, Hrafnkelsson, Jon, Sturgis, Erich M., Brock, Pamela, Nabhan, Fadi, Thorleifsson, Gudmar, Ringel, Matthew D., Stefansson, Kari, de la Chapelle, Albert
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2020
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7084156/
https://ncbi.nlm.nih.gov/pubmed/32132206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1919976117
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