Degree and site of chromosomal instability define its oncogenic potential

Most human cancers are aneuploid, due to a chromosomal instability (CIN) phenotype. Despite being hallmarks of cancer, however, the roles of CIN and aneuploidy in tumor formation have not unequivocally emerged from animal studies and are thus still unclear. Using a conditional mouse model for divers...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Hoevenaar, Wilma H. M., Janssen, Aniek, Quirindongo, Ajit I., Ma, Huiying, Klaasen, Sjoerd J., Teixeira, Antoinette, van Gerwen, Bastiaan, Lansu, Nico, Morsink, Folkert H. M., Offerhaus, G. Johan A., Medema, René H., Kops, Geert J. P. L., Jelluma, Nannette
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7083897/
https://ncbi.nlm.nih.gov/pubmed/32198375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15279-9
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